Glymphatic Dysfunction Correlate with Spatial Navigation Deficits in Subjective Cognitive Decline: Insights from 5.0T MRI and Plasma Biomarkers Analysis

Abstract

Background: Glymphatic system dysfunction is implicated in cognitive impairments in Alzheimer's Disease (AD), particularly in early symptomatic stages like subjective cognitive decline (SCD). The link between glymphatic function and spatial navigation, a key early symptom, is not well‐understood.