Plasma biomarkers
Biomarker1 paper1 finding
- Humans1
Associations
1Clinical progression from CN to MCI/AD
upin humans1
1 study
Clinical progression from CN to MCI/AD
upin humans1
Plasma biomarkers are associated with clinical progression from CN to MCI/AD in humans.
Humansin initially cognitively normal participants
Plasma biomarker and machine learning modeling of clinical progression in cognitively normal individuals at risk for Alzheimer's disease · Neurodegenerative disease management · 20 Sep 2026
Funding
National Institute on AgingUS$10.8m3 grants since 2023
National Institute on AgingIcahn School of Medicine at Mount SinaiUS$5.5m2025–2030
National Institute on AgingUniversity of UtahUS$5m2025–2030
National Institute on AgingRutgers Biomedical and Health SciencesUS$246.7k2023–2028
Latest
208Plasma biomarkers of vitamin B6 homeostasis and the risk of stroke in individuals with type 2 diabetes: a nested case-control study
Gene variant linked to lower brain scan signals in women
An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or…An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or activity.
Lifestyle trial found similar Alzheimer’s blood marker changes
A two-year randomised trial in 1,260 older adults at risk of dementia found no clear evidence that starting blood markers altered cognitive benefits.A two-year randomised trial in 1,260 older adults at risk of dementia found no clear evidence that starting blood markers altered cognitive benefits.
Exploratory Analysis of APOE ε4-Stratified Associations Between Plasma Alzheimer's Biomarkers and Retinal Imaging Metrics in Cognitively Normal Adults
App knock-in mice display age-dependent Alzheimer's pathology
In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and…In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and synaptic loss.
Stronger rest-activity rhythms link to better executive function
Across 169 older adults followed over three years, stronger 24-hour activity rhythms tracked with better executive function and reduced risk of mild…Across 169 older adults followed over three years, stronger 24-hour activity rhythms tracked with better executive function and reduced risk of mild cognitive impairment.
Immune cell profiles predict cognitive decline in older adults
In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63…In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63 over six years.