Aged T-cells

1 paper1 finding

Humans1

Effects

1

Mortality

mediatesin humans1

1 study

Aged T-cells mediate mortality in humans.
“Elevated levels of aged T-cells partially mediated the relationship between widowhood and mortality, with a stronger mediating effect observed in men than in women.”
HumansPartial mediation of the widowhood–mortality association; stronger in men than womenT cell
Widowhood, immune aging, and mortality in older Americans: evidence from the US Health and Retirement Study
The journals of gerontology. Series A, Biological sciences and medical sciences12 May 2026

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The Journals of Gerontology, Series A12 May

Widowhood, immune aging, and mortality in older Americans: evidence from the US Health and Retirement Study

Cohort study of 8,410 peopleBlood and immune system

AIDS27 Mar

Age and viral replication, not vertical HIV acquisition, drive inflammation and T-cell dysfunction in heavily treatment experienced: data from the Prestigio Registry

Cohort study in peopleInflammation

Cancers23 Dec

Implications of Senescent T Cells for Cancer Immunotherapy

ReviewMechanisms

Aging Cell14 Oct

STAT3 modulates CD4⁺ T mitochondrial dynamics and function in aging

Experiments in cellsMechanisms

Current Atherosclerosis Reports3 Jul

T-cell Cholesterol Accumulation, Aging, and Atherosclerosis

ReviewMechanisms

Cardiovascular Research4 May

An interferon gamma response signature links myocardial aging and immunosenescence

Experiments in animalsMechanisms

Human Immunology14 Oct

Loss of immune regulation in aged T-cells: A metabolic review to show lack of ability to control responses within the self

ReviewMechanisms

PNAS8 Oct

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

Experiments in miceCellular homeostasis