There is 1 paper on age-related disease-associated microglia expansion in aging research: 1 observational study in people.
1 paper studies it2 findings
See all 1 papers on age-related disease-associated microglia expansion
- Humans1
Interventions
1CSF1R antagonist
no changein mice1
1 study
CSF1R antagonist
no changein mice1
CSF1R antagonist showed no clear effect on age-related disease-associated microglia expansion in mice (pharmacological depletion and repopulation of microglia).
“The age-related expansion of DAM was unaffected by pharmacological depletion and repopulation of microglia with a CSF1R antagonist or genetic gain or loss of function of the phagocytic receptor MERTK”
Animalspharmacological depletion and repopulation of microgliamales
Influenza A infection accelerates disease-associated microglia formation during physiological aging
bioRxiv : the preprint server for biologyPreprint
Upstream
1MERTK
no changein mice1
1 study
MERTK
no changein mice1
MERTK showed no clear effect on age-related disease-associated microglia expansion in mice (genetic gain or loss of function).
“The age-related expansion of DAM was unaffected by pharmacological depletion and repopulation of microglia with a CSF1R antagonist or genetic gain or loss of function of the phagocytic receptor MERTK”
Animalsgenetic gain or loss of functionmales
Influenza A infection accelerates disease-associated microglia formation during physiological aging
bioRxiv : the preprint server for biologyPreprint