Age-related chromatin accessibility changes

1. Aav-mediated SIRT6 gene therapy decreases age-related chromatin accessibility changes in mice.

   “SIRT6 not only slows age-related chromatin changes but can also reverse them, rejuvenating chromatin accessibility to a youthful state.”

   AnimalsAAV-mediated overexpressionlivermales

   SIRT6 overexpression counteracts chromatin aging in the male murine liver

   Nature communications·14 May 2026

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