Age prediction
Biomarker1 paper
- Humans1
Latest
16Retinal age gap in unilateral retinal diseases with unaffected fellow eye: phakia and vascular pathology impact retinal age prediction
Ovarian stiffness increases with age and tracks with declining egg yield
Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.
Repeat-consistency learning for improving repeatability of brain-age prediction from structural MRI
Accelerated biological aging links to higher gout risk and increased mortality
Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival.Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival.
Chronological age prediction does not prove biological age measurement
Researchers show that standard age-trained clocks reflect task-specific statistics rather than true biological aging constructs, limiting how…Researchers show that standard age-trained clocks reflect task-specific statistics rather than true biological aging constructs, limiting how researchers interpret clock gaps and rejuvenation.
DECIPHER decodes cell types and predicts age from bulk omics
Tested across multiple molecular platforms, the framework separates technical variation from biological signal to infer cell proportions and…Tested across multiple molecular platforms, the framework separates technical variation from biological signal to infer cell proportions and chronological age across independent human cohorts.
Tool maps spatial cell-cell signals in brain aging and cancer
Applied to over 5.8 million spatially profiled cells, the framework identified a T-cell-associated brain-aging program and signals that predicted age…Applied to over 5.8 million spatially profiled cells, the framework identified a T-cell-associated brain-aging program and signals that predicted age across regions.
Single-cell foundation models show task-dependent utility for aging biology research
A benchmark across 2.5 million single-cell transcriptomes reveals strengths in detecting rare cell states and gene networks, though simple gene sets…A benchmark across 2.5 million single-cell transcriptomes reveals strengths in detecting rare cell states and gene networks, though simple gene sets predicted age better.