FASEB Journal·Sep 23ADP Inhibits Macrophage Senescence via the AMPK/KLF10 Pathway in Systemic Lupus ErythematosusExperiments in miceAMPK signalingPaper
Yakugaku Zasshi·Apr 30Function, Regeneration, and Proliferation of Pancreatic β-Cells Centered on NADReviewMechanismsPaper
Journal of the American Chemical Society·Jun 13A Nucleic Acid Prodrug That Activates Mitochondrial Respiration, Promotes Stress Resilience, and Prolongs LifespanExperiments in wormsInterventionsPaper
Bioinformatics and Biology Insights·May 26Structural Insights Into centSIRT6: Bioinformatic Analysis of N308K and A313S Substitution EffectsComputational studyMechanismsPaper
Biotechnology Journal·Feb 1Efficient Conversion of Nicotinamide Mononucleotide Based on Elucidation of the Limitations in Multienzyme Cascade ReactionsExperiments in cellsNicotinamide mononucleotidePaper
Ageing Research Reviews·Sep 8Neuroenergetic alterations in neurodegenerative diseases: A systematic review and meta-analysis of in vivo³¹P-MRS studiesMeta-analysis of observational studiesNeurodegenerative diseasePaper
GeroScience·Jul 18The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)Experiments in animalsInterventionsPaper
Frontiers in Immunology·May 22Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout miceExperiments in miceNAD+ precursorsPaper
Aging and Disease·May 16Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and ModulatorsReviewSirtuin signalingPaper
Journal of Cachexia, Sarcopenia and Muscle·May 5Evidence for inefficient contraction and abnormal mitochondrial activity in sarcopenia using magnetic resonance spectroscopyCross-sectional study in peopleMitochondrionPaper
Research and Practice in Thrombosis and Haemostasis·Mar 10Impact of age on in vitro metabolism of clopidogrel: a potential explanation for high on-treatment platelet reactivity in the elderly?Experiments in human cellsMechanismsPaper
MAbs·Jul 22TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activityExperiments in cellsInterventionsPaper
Frontiers in Pharmacology·Jun 28Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma-Induced Cancer CachexiaExperiments in miceNicotinamide ribosidePaper
International Journal of Molecular Sciences·Jun 3Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in CancerReviewMechanismsPaper
British Journal of Pharmacology·Apr 5Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageingReviewMechanismsPaper
JCSM Rapid Communications·Jan 1Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervationExperiments in animalsMechanismsPaper
The Journal of International Medical Research·Jul 25Multiple functions of policosanol in elderly patients with dyslipidemiaTrial in peopleInterventionsPaper
Clinical and Applied Thrombosis/hemostasis·Apr 30Association of Frailty With Antiplatelet Response Among Elderly Chinese Patients With Coronary Artery Disease Undergoing Percutaneous Coronary InterventionCross-sectional study of 264 peopleCoronary artery diseasePaper
Autophagy·Dec 3The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespanExperiments in cellsAMPK signalingPaper
PNAS·Jul 24Identification of evolutionary and kinetic drivers of NAD-dependent signalingExperiments in cellsMechanismsPaper
Hepatology·Dec 15Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine-Monophosphate-Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in MiceStudy in peopleMechanismsPaper
Nucleosides, Nucleotides & Nucleic Acids·Nov 2The effects of pro- and anti-atherosclerotic factors on intracellular nucleotide concentration in murine endothelial cellsExperiments in mouse cellsInterventionsPaper
Rejuvenation Research·Aug 21The Plasma NAD⁺ Metabolome Is Dysregulated in "Normal" AgingCross-sectional study in peopleNAD+ metabolismPaper
Science·May 10Metabolic regulation of transcription through compartmentalized NAD⁺ biosynthesisExperiments in cellsMechanismsPaper
Physiological Reports·May 24Relationship between monocyte-platelet aggregation and endothelial function in middle-aged and elderly adultsStudy in peopleMechanismsPaper
Nutrition·Mar 1Short fasting does not protect perfused ex vivo rat liver against ischemia-reperfusion. On the importance of a minimal cell energy chargeExperiments in animalsFastingPaper
International Journal of Molecular Sciences·Jan 29Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical CompoundsReviewInterventionsPaper
Journal of Molecular and Cellular Cardiology·Aug 19Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissectionExperiments in micePurinergic (ATP) signalingPaper
Journal of Thrombosis and Thrombolysis·May 12Prasugrel 5 mg inhibits platelet P-selectin and GPIIb-IIIa expression in very elderly and non elderly: results from the GENERATIONS trial, a pharmacodynamic study in stable CAD patientsTrial in peopleInterventionsPaper
Circulation Journal·Mar 11Regenerated Endothelium and Its Senescent Response to Aggregating PlateletsReviewCellular senescencePaper