[11C]DTBZ binding

[11C]DTBZ binding is associated with performance fatigability in humans (Beta = -1.03, 95% CI: -2.02, -0.10).

“Higher [11C]-DTBZ binding in the posterior putamen was significantly associated with lower performance fatigability”

Humansposterior putamenn = 125

NIGROSTRIATAL DOPAMINE AND PHYSICAL PERFORMANCE FATIGABILITY IN COMMUNITY-DWELLING OLDER ADULTS

GSA 2024 abstract·31 Dec 2024

[11C]DTBZ binding is associated with percent change in gait speed in humans (β=0.238, p=0.01).

“in those with ≥1 PSRF (but not in those with no PSRF), posterior putamen [11C]DTBZ binding was associated with %CGS (β=0.238, p=0.01) independent of potential confounders”

Humansin individuals with ≥1 peripheral systemic risk factor (obesity, joint pain, or reduced muscle strength)posterior putamenn = 131

GAIT SLOWING ON TRANSITION TO UNEVEN SURFACES: DOPAMINERGIC NEUROTRANSMISSION AND PERIPHERAL SYSTEM RISK FACTORS

GSA 2024 abstract·31 Dec 2024