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Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.
In 4,392 healthy Chinese adults, standard medical reference ranges flagged 58.8% of women aged 50 to 59 as having abnormal cholesterol.In 4,392 healthy Chinese adults, standard medical reference ranges flagged 58.8% of women aged 50 to 59 as having abnormal cholesterol.
An experiment in rats linked the chemical’s effects to fumarate, a substance involved in metabolism, and DNA escaping from cells’ energy-producing structures.An experiment in rats linked the chemical’s effects to fumarate, a substance involved in metabolism, and DNA escaping from cells’ energy-producing structures.
In UK Biobank participants, higher birthweight was associated with slower aging in 11 organs, while breastfeeding was linked to slower intestine and adrenal aging.In UK Biobank participants, higher birthweight was associated with slower aging in 11 organs, while breastfeeding was linked to slower intestine and adrenal aging.
The engineered particles cut friction over 90% compared with commercial hyaluronic acid and reversed chondrocyte senescence in lab models of osteoarthritis.The engineered particles cut friction over 90% compared with commercial hyaluronic acid and reversed chondrocyte senescence in lab models of osteoarthritis.
In people with MASLD, drinking 1 to 2 cups of tea daily was linked to an all-cause mortality hazard ratio of 0.85 versus none.In people with MASLD, drinking 1 to 2 cups of tea daily was linked to an all-cause mortality hazard ratio of 0.85 versus none.
In 503 retired adults in China, each 0.1-micrometre rise in a marker of vessel lining damage was linked to 12% higher odds of asymptomatic heart dysfunction.In 503 retired adults in China, each 0.1-micrometre rise in a marker of vessel lining damage was linked to 12% higher odds of asymptomatic heart dysfunction.