121 results
In mice lacking ovaries to mimic estrogen loss, deleting the Camkk1 gene from bone-degrading cells attenuated the loss of spongy bone.In mice lacking ovaries to mimic estrogen loss, deleting the Camkk1 gene from bone-degrading cells attenuated the loss of spongy bone.
In adults with preclinical obesity, ultrasound-defined fatty liver was associated with an adjusted hazard ratio of 1.59 for progression to clinical obesity.In adults with preclinical obesity, ultrasound-defined fatty liver was associated with an adjusted hazard ratio of 1.59 for progression to clinical obesity.
In 130,489 Chinese adults with high blood pressure followed for 6–36 months, combined blood sugar and fat measures were more strongly linked to risk than traditional…In 130,489 Chinese adults with high blood pressure followed for 6–36 months, combined blood sugar and fat measures were more strongly linked to risk than traditional indicators.
In 70,473 adults followed for up to 10 years, 210 wearable activity phenotypes were linked to 406 diseases, with step intensity and circadian rhythm showing prominent…In 70,473 adults followed for up to 10 years, 210 wearable activity phenotypes were linked to 406 diseases, with step intensity and circadian rhythm showing prominent ties.
Across 207,887 participants in a meta-analysis, current smoking was associated with all-cause dementia risk exclusively among APOE ε4 noncarriers.Across 207,887 participants in a meta-analysis, current smoking was associated with all-cause dementia risk exclusively among APOE ε4 noncarriers.
Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic multimorbidity.Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic multimorbidity.
In over 119,000 adults, 89.2% of COPD cases were underdiagnosed, which was associated with a 1.53 hazard ratio for mortality compared to having no COPD.In over 119,000 adults, 89.2% of COPD cases were underdiagnosed, which was associated with a 1.53 hazard ratio for mortality compared to having no COPD.
Across eight external cohorts, the score yielded C-indices of 0.67 to 0.86, outperforming recalibrated conventional comorbidity indices by absolute gains of 0.12 to 0.21.Across eight external cohorts, the score yielded C-indices of 0.67 to 0.86, outperforming recalibrated conventional comorbidity indices by absolute gains of 0.12 to 0.21.