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Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.
In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.
Each one-percentage-point increase in red blood cell distribution width was linked to an 8% higher hazard of hip fracture over 14 years.Each one-percentage-point increase in red blood cell distribution width was linked to an 8% higher hazard of hip fracture over 14 years.
An animal study mapped gene activity in mouse livers of multiple ages, linking senescence patterns to changes in gene patterns defining specialised liver zones.An animal study mapped gene activity in mouse livers of multiple ages, linking senescence patterns to changes in gene patterns defining specialised liver zones.