Blood and body-size scores linked to cardiovascular risk
In 5,304 Chinese adults, one score was linked to new cardiovascular disease with a hazard ratio of 1.213 per standard-deviation increase.
Our read
Biomarkers- Studied:
- Preprint: cohort study of 5,487 people (Independent replication)
- In the record:
- One of 3 papers on CHG-CVAI on record: 3 with results in people.
Editor of record: Boris Djordjevic · AgingResearch.News
Chinese adults aged 45 or older with stages 0–3 of cardiovascular-kidney-metabolic syndrome—a classification of heart, kidney and metabolic health—were studied in a cohort analysis. Researchers analyzed 5,304 Chinese adults and 5,487 US participants, comparing 16 scores combining blood-test and body-size measures. One score combined measures of inflammation, blood fat and sugar with an abdominal-fat index. Its hazard ratio compared event rates over time for a standard-deviation increase, a measure of variation in scores.
Two metabolic indices, paired with body-size indices, showed the strongest and most consistent links to new, self-reported cardiovascular disease in China and cardiovascular death in the US. The best body-size index differed between cohorts. No improvement in distinguishing people with and without an outcome met the statistical threshold after accounting for multiple comparisons. Some scores improved risk categorization.
Why it matters
For assessing cardiovascular risk as people age, the authors favored using these scores to summarize existing risk, rather than using them for screening before external validation.
Caveats
Prediction performance was assessed within the source cohorts, leaving performance in other populations or more advanced disease unvalidated. This preprint has not yet been peer-reviewed.
- Modeling and theory
- Cardiovascular disease
- Cardiovascular-kidney-metabolic syndrome
- A body shape index
- Atherogenic index of plasma
- Humans
The paper
Hunan University of Traditional Chinese Medicine
Research Square, Nov 12, 2026, Open access, Preprint, not yet peer-reviewed
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