Research Square

Frailty and the Incidence of Major Ocular Diseases: A Prospective Cohort Study Integrating Proteomic Mediation Analysis

Preprint: cohort study in peoplePopulations

15.7 years

Abstract

Background The long-term association between frailty phenotype and major vision-threatening ocular diseases (age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, and cataract), as well as the underlying molecular mechanisms, remain unclear.

The paper

First Affiliated Hospital of Xi'an Jiaotong University; Xinjiang Medical University

Research Square, 18 Aug 2026, CC BY, Preprint, not peer-reviewed

doi.org/10.21203/rs.3.rs-10152825/v1