Frontiers in Aging Neuroscience

Parkinson’s linked to less everyday walking in Ghana

In Ghana, daily steps were 2,153 in people with Parkinson’s versus 10,001 in controls during seven days of wearable monitoring.

Figure 1. On the left panel, radar plot showing comparisons of digital mobility outcomes between the two populations of people from Ghana.
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Figure 1. On the left panel, radar plot showing comparisons of digital mobility outcomes between the two populations of people from Ghana.On the left panel, radar plot showing comparisons of digital mobility outcomes between the two populations of people from Ghana.Bicer et al.
Cross-sectional study of Ghanaian adults with and without Parkinson's disease, seven daysPopulations

50 participants

Limit: Unmeasured comorbidities could partly explain the walking difference

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In an observational study, 50 people with Parkinson’s disease and 30 older people without the disease in Ghana wore a movement-tracking device for seven days. Researchers calculated 24 measures of everyday mobility. They also included age- and gender-matched Parkinson’s and control groups from an earlier UK study.

Sixteen mobility measures differed between the Ghanaian groups. Daily walking time was 0.43 hours in people with Parkinson’s, compared with 2.07 hours in controls. Mobility impairment was more pronounced in the Ghanaian Parkinson’s group than in its UK counterpart. Differences remained in 18 measures after adjustment for other factors. The monitoring method had high feasibility and acceptability in Ghana, although participants commonly reported discomfort.

Why it matters

Parkinson’s-related walking difficulties can threaten everyday function and independence. Understanding how they present in African populations matters as life expectancy and Parkinson’s prevalence rise.

Caveats

This observational comparison could not establish what caused the mobility differences. The Ghanaian findings came from 50 people with Parkinson’s and 30 older controls.

From the paper

Result

Compared with the UK-PD cohort, the GHA-PD cohort took, on average, 3,340 fewer daily steps per day (β = −3340, 95% CI −5002 to −1679) and completed 174 fewer daily WBs per day (β = −174, 95% CI −227 to −123).

Results, 3.3 Exploring context in two geographically distant cohorts of people with Parkinson’s disease: Ghana vs. United Kingdom

Limitation

First, residual confounding from unmeasured factors (e.g., nutrition, comorbidities, habitual physical activity, environmental factors, socioeconomic context, social support and depressive symptoms) likely remains.

4.6 Limitations

Quoted word for word from the full text on frontiersin.org.