The heat shock factor Cbr-HSF-1 is necessary for lifespan maintenance in C. briggsae

The heat shock response is a conserved mechanism that plays a critical role in organismal survival under thermal stress. Caenorhabditis briggsae is a widely used model organism for comparative studies involving its well-known cousin C. elegans and exhibits increased thermotolerance under heat stress. In C. elegans , the transcription factor HSF-1 has been well characterized for its role in many processes including development, thermotolerance, and lifespan. We recently showed that Cbr- hsf-1 is necessary for fertility and protection against heat stress. Here, we report that Cbr- hsf-1 also plays essential roles during development and adulthood to maintain the lifespan of animals.&nbsp.