Targeting the liver for longevity

The liver performs a wide range of physiological functions, including lipid/glucose metabolism, energy storage, immune regulation, molecular biosynthesis, and the clearance of xenobiotics, all of which are essential for maintaining systemic homeostasis. Liver ageing increases its susceptibility to acute stress and injury, which in turn enhances the body's sensitivity to ageing-related responses. These processes interact with other organs, accelerating systemic ageing and the pathogenesis of age-related diseases. Growing evidence indicates that targeting liver-specific pathways can promote longevity. This review summarizes the effects of longevity interventions on the liver ageing process and their underlying mechanisms, and offers perspectives on liver-targeted longevity strategies for delaying ageing and treating age-related diseases.