Longevity interventions

1. Longevity interventions improve longevity.

   “Growing evidence indicates that targeting liver-specific pathways can promote longevity.”

   Review

   Targeting the liver for longevity

   Ageing research reviews·Apr 15, 2026

1. Longevity interventions improve extracellular matrix remodeling in worms.

   “Longevity interventions slow age-related collagen stiffening and prolong the expression of collagens that are turned over.”

   Model organisms

   Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

   Nature communications·Jan 4, 2024

More on Extracellular matrix remodeling

1. Longevity interventions have no effect on sickspan in worms.

   “Surprisingly, we did not observe a compression of sickspan in longevity mutants but instead observed a temporal scaling of healthspan.”

   Model organismsin longevity mutants

   Longevity interventions temporally scale healthspan in Caenorhabditis elegans

   iScience·Feb 24, 2022