The association between gait speed and depressive disorders - A cross-sectional analysis of very old adults in the 21st century

OBJECTIVES: To investigate the association between gait speed and depressive disorders among very old adults (≥85 years). METHOD: This study utilized the GERDA-database, which encompasses a representative sample of those aged 85, 90, and 95+ years residing in northern Sweden and western Finland. From four data collections between 2000 and 2017, this study included 1794 participants. Self-paced gait speed was measured over 2.4-m and depressive disorders was evaluated by a specialist in geriatric medicine according to the DSM-IV-TR criteria. T-tests and multivariable logistic regressions were used to explore differences and associations between gait speed and depressive disorders. RESULTS: Gait speed was independently associated with depressive disorders among very old adults (p < .001). The results showed significantly different mean gait speeds (m/s) between individuals with/without a depressive disorder (0.34 ± 0.24/0.52 ± 0.26, p < .001), between individuals with a depressive disorder with/without antidepressant treatment (0.35 ± 0.24/0.44 ± 0.24, p < .001) and between non-responders/responders to antidepressants (0.36 ± 0.21/0.42 ± 0.22, p = .020). CONCLUSION: This is the first study focusing on very old adults that has shown an independent association between gait speed and depressive disorders. Responders to antidepressant medication had a higher mean gait speed than non-responders, which may imply shifts in function upon successful treatment.