Cell Stem Cell
A mechanical niche promotes the rejuvenation of blood stem cells
CommentaryInterventions
Abstract
Zhang et al.¹ show that the mechanical properties of a three-dimensional (3D) hydrogel can enhance the secretion of niche factors from bone marrow stromal cells, which in turn promotes the maintenance of hematopoietic stem cells (HSCs) and reverses aging hallmarks in HSCs.
The paper
University of California, Los Angeles
Cell Stem Cell, Apr 6, 2023, Open access
