Quantification of domain-specific intrinsic capacity using mortality data

Abstract Functional health is centered on five domains of Intrinsic Capacity (IC): locomotion, cognition, vitality, psychological and sensory capacity. Therefore, measuring IC at the domain-specific level is the cornerstone for developing preventive interventions to help individuals preserve their independence. In this study, we used 63 clinical features from the UK Biobank to develop ‘IC age’, an 18-year mortality risk estimator that approximates an individual’s biological age associated with the decline of each IC domain. By establishing proteomic surrogates of IC age, we find immune system activation across domains and provide a proteomic framework that may facilitate scalable monitoring of functional health decline.