Why Glutamate-Oxaloacetate Transaminase can be used as a biomarker for liver damage?

Glutamate-Oxaloacetate Transaminase is a biomarker for organ damage. However, the underlying mechanism is not fully known. The rise of Glutamate-Oxaloacetate Transaminase activity enhances the conversion of oxaloacetate to aspartic acid, resulting in lower levels of oxalate from breakdown of oxaloacetate. The insoluble and stiff calcium oxalate was proposed as a cause of cell senescence and death. Therefore, Glutamate-Oxaloacetate Transaminase reduces stress generated from energy metabolism, serving as a self-protecting mechanism upon organ damage.