Real-World Outcomes of a Fasting Mimicking Diet Program for Type 2 Diabetes Management

Introduction and Objective: An ADA consensus report highlights the potential of intensive lifestyle interventions to improve glycemic control and reduce medication burden in type 2 diabetes (T2D). This study evaluates the real-world efficacy of a medically supervised diabetes management program incorporating the Fasting Mimicking Diet (FMD). Methods: Participants with T2D completed up to eight monthly cycles of a 5-day FMD, designed to mimic fasting physiology while providing essential nutrition (Day 1, 1100 kcal; Days 2 - 5, 720 kcal). The program included bi-weekly support and behavioral coaching from registered dietitians (RDs), and quarterly physician-led (MD) diabetes medication adjustments aimed at optimizing glycemic control and reducing diabetes medication. Results: A total of 128 patients enrolled. Data from 74 participants at 3 months and 29 at 6 months who completed at least 3 months were analyzed. The proportion achieving HbA1c <7% increased from 49% at baseline to 70% at 3 months (p<0.001) and 62% at 6 months (p<0.05). Diabetes medication was reduced in 73% and 68% of patients at 3 and 6 months, respectively. Mean HbA1c decreased by 0.54% ± 0.84% at 3 months and 0.53% ± 0.73% at 6 months, with significant weight loss (-4.5 kg ± 3.5 and -6.7 kg ± 4.5; p<0.0001). Engagement was high, with a 94% RD/MD appointment show rate and a Net Promoter Score of 92. Conclusion: This innovative FMD-based lifestyle program, supported by RDs and supervised by MDs, effectively improves glycemic control, reduces medication burden, and promotes weight loss with high engagement and satisfaction, offering a promising new model for T2D management. Disclosure: A. Bizzell: Employee; L Nutra, Inc. T. Hall: None. N.K. Grant: Employee; L-Nutra. C.A. Margolin: Employee; L-Nutra. M. Wei: Employee; L-NUTRA INC. W. Hsu: Employee; L-Nutra, Inc.