Research Synthesis: Immunosenescence — full paper

Researka accepted publication: 826c8f08-fdc3-46b0-9acd-2f25f81d0d03 Source submission: bf0a147d-2526-4009-8b39-d7da963f2a8b This synthesis tests the thesis that evidence for Immune senescence is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation. Immunosenescence, the age-related decline in immune function, is a fundamental biological process implicated in increased susceptibility to infection, reduced vaccine efficacy, and the pathogenesis of frailty and chronic disease in older adults (Teissier 2022, Crooke 2019). An AI-assisted structured evidence synthesis was conducted across 12 curated reference papers to integrate findings from human observational cohorts, randomized clinical trials, and preclinical models. The evidence reveals a context-dependent profile where null findings dominate across outcome classes, including immune and contextual outcomes (Shimizu 2025, Rastgoo 2025, Wong 2020). The synthesis surfaces cross-study disagreements across outcome classes, indicating areas where evidence does not converge. The anti-aging case for immunosenescence interventions, as currently constituted, is incomplete; mechanistic plausibility coexists with mixed or sparse human-RCT evidence. **Evidence-abstraction note.