B and T Lymphocyte Densities in Aging Human Cortex

Densities of lymphocytes in human cortex per research subject (listed by age and sex) as defined by CD3 or CD20-positively stained cells on pathology slides. Files were created on 08/31/2019. For the pilot study, we obtained “normal” cortical tissue from two sources: the Rush Alzheimer’s Disease Center Pathology Core/Rush Memory and Aging Project and Rush Religious Orders Study (Bennett et al., 2012a, 2012b), and the Department of Pathology of Stanford University. Six Stanford subjects were selected from a cohort of 72 participants (ages 44–69) whose brains were examined in Stanford University Dept. of Pathology autopsies between 2014 to 2016. We additionally selected 20 subjects less than 65 years old (44–62 years), and 20 subjects 65 years and older (65–89 years), from a collection of 1,092 brains at the Universidade de São Paulo Biobank for Aging Studies (Suemoto et al., 2017). Clinical data were reviewed, and brain tissue was examined macroscopically and microscopically by at least one pathologist. Inclusion criteria were normal cognition (Clinical Dementia Rating = 0), and without significant neuropathological lesions observed on hematoxylin-eosin stain, and immunostains for beta-amyloid, phosphorylated tau, alpha-synuclein, and TDP-43. Data is displayed in Figure 1 of publication.