Research Synthesis: Senescence Cancer Effects — full paper

Researka accepted publication: ad6bd204-1859-4516-b412-8f3a7f40f350 Source submission: ead71d06-27c9-4bd2-b397-a22e518393db This paper synthesizes evidence on senescence cancer effects across 13 accepted source papers and 220 high-confidence extracted claims. The evidence profile contains no sources classified primarily as direct clinical evidence, 13 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 0 cross-study disagreements across the evidence base. No single positive outcome class dominates the retained corpus; null signals cluster in the contextual adjacent evidence, muscle function, immune and inflammation outcome classes, and negative signals cluster in no dominant outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that senescence cancer effects remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.