Creatine linked to better cognitive test results in women
In a 28-day randomized trial of 48 young and older women, creatine was associated with improvements on several cognitive tests compared with placebo.
28 days, placebo-controlled
Edited by Boris Djordjevic · AgingResearch.News
Forty-eight women—26 young and 22 older—took part in a randomized trial comparing creatine monohydrate supplementation with placebo. They received 3 grams daily or placebo for 28 days. Researchers tested cognitive functioning before and after supplementation. Their analysis accounted for differences in estimated daily creatine consumption at the start.
Creatine supplementation was associated with improvements in several cognitive measures in both age groups compared with placebo. The most consistent findings involved visual and auditory reaction times; inhibitory control, the ability to resist an automatic response; and working memory, which holds information briefly for use. A second statistical approach supported some comparisons, particularly among older women. The authors highlighted greater cognitive responses in older women.
Why it matters
The study addressed whether age affects cognitive responses to creatine. The authors suggested a possible role in mitigating age-related cognitive decline that warrants confirmation in future, hypothesis-driven trials.
Caveats
This small, exploratory trial assessed short-term test performance, not long-term cognitive decline. The results concern women only, and the abstract does not report effect sizes or adverse events.
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The paper
Creatine Supplementation on Cognition in Young and Old Active Females
Universidade Iguaçu Campus V; Fundação Universitária de Itaperuna
Biological Research for Nursing, Nov 2, 2026
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