SERUM FACTORS DRIVE DIFFERENCES IN MITOCHONDRIAL BIOENERGETICS ASSOCIATED WITH HUMAN AGING
GSA 2024 Abstract
Abstract
Heterochronic parabiosis studies in mice have demonstrated that circulating factors in blood drive multiple features of aging, including mitochondrial bioenergetic decline. To determine if circulating factors in human blood can drive age-related bioenergetic decline, we treated fibroblasts from younger (33y.o.) and older (72y.o.
- Human serum
- Epigenetic regulation of gene expression
- Oxidative phosphorylation
- GrimAge
- Hannum's clock
- Humans
