Brachionus asplanchnoidis

1. Metformin decreases S-adenosylmethionine in B. asplanchnoidis.

   “decreased MTR expression and lowered levels of S-adenosylmethionine (SAM)”

   Model organisms

   Metformin and Dietary Restriction Counteract Aging via Reducing m6A-Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

   Aging cell·27 May 2025

2. Metformin decreases MTR in B. asplanchnoidis.

   “reduction in the m6A modification of MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). This reduction led to decreased MTR expression”

   Model organisms

   Metformin and Dietary Restriction Counteract Aging via Reducing m6A-Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

   Aging cell·27 May 2025

3. Metformin extends lifespan in B. asplanchnoidis.

   “metformin significantly extended the rotifers' lifespan”

   Model organisms

   Metformin and Dietary Restriction Counteract Aging via Reducing m6A-Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

   Aging cell·27 May 2025

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