The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time
bioRxiv
Abstract
BACKGROUND: Cognitive resilience to Alzheimer's disease (AD) can be modelled in amyloid-expressing rodents through early handling (EH). This study investigated how EH and sex affect cognition and pathology over time.
The paper
M. Carrigan, J. Sanguino-Gomez, M. Bayer-Var, H. J. Krugers
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O. Minko, A. Bobkova, E. Ruzicka, L. Lopez-Fedjajeva, N. Renckens, L. Givalois, P. J. Lucassen, R. Ossenkoppele,Amsterdam University Medical Center
bioRxiv · 5 Oct 2026 · CC BY · Preprint, not peer-reviewed
