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Young plasma small extracellular vesicles

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 3 more
  • Animals1

Outcomes

4

Oxidative phosphorylation

upin mice1

1 study

  1. Young plasma small extracellular vesicles improve oxidative phosphorylation in mice.

    “improving mitochondrial functions and mitigating mitochondrial deficits in aged tissues”

    Animalsplasma small extracellular vesicles

    Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

    Nature aging16 Apr 2024

More on Oxidative phosphorylation

PPARGC1A

upin mice1

1 study

  1. Young plasma small extracellular vesicles increase PPARGC1A in mice.

    “young sEVs stimulate PGC-1α expression in vitro and in vivo through their miRNA cargoes”

    Animalsplasma small extracellular vesicles

    Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

    Nature aging16 Apr 2024

More on PPARGC1A

Cellular senescence

downin mice1

1 study

  1. Young plasma small extracellular vesicles decrease cellular senescence in mice.

    “mitigates senescent phenotypes and ameliorates age-associated functional declines in multiple tissues”

    Animalsplasma small extracellular vesicles

    Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

    Nature aging16 Apr 2024

More on Cellular senescence

Lifespan

upin mice1

1 study

  1. Young plasma small extracellular vesicles extend lifespan in mice.

    “Intravenous injection of young sEVs into aged mice extends their lifespan”

    Animalsplasma small extracellular vesicles

    Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

    Nature aging16 Apr 2024

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