CD36+ extracellular vesicles

1. Weight loss intervention decreases CD36+ extracellular vesicles in humans (-1.9-fold).

   “We saw similar responses for the CD36+‐EVs (Figure and Table ), with a 1.6‐fold decrease from baseline (9.6 × 106 EVs/mL) to 1 month (4.2 × 106 EVs/mL; β = −0.46; CI: −0.74 to −0.17; p = 0.002) and 1.9‐fold reduction after 5 months (3.3 × 106 EVs/mL; β = −0.65; CI: −0.93 to −0.36; p < 0.001).”

   Human trial20–24 weeks

   Circulating Liver-Derived and CD36⁺ Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weight Loss Intervention

   Journal of extracellular vesicles·Mar 1, 2026

2. Weight loss intervention decreases CD36+ extracellular vesicles in MASLD.

   “During intervention, levels of both ASGR1+-EVs, CD36+-EVs and ASGR1+CD36+-EVs were significantly decreased in the MASLD group already at 1 month and further reduced after 5 months.”

   Human trialin MASLD

   Circulating Liver-Derived and CD36⁺ Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weight Loss Intervention

   Journal of extracellular vesicles·Mar 1, 2026

More on Weight loss intervention

1. CD36+ extracellular vesicles are associated with liver fat content in humans (r = 0.38).

   “Correlation of concentrations of EV‐populations with selected clinical parameters across all studied groups at baseline showed that CD36+‐EV levels correlated, although not strongly, with liver fat content (r = 0.38; p = 0.003”

   Humans20–24 weeks

   Circulating Liver-Derived and CD36⁺ Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weight Loss Intervention

   Journal of extracellular vesicles·Mar 1, 2026

2. CD36+ extracellular vesicles are associated with liver fat content in individuals with obesity and MASLD.

   “Finally, we found that CD36+-EV levels correlated with liver fat content, total body fat, and markers of liver fibrosis.”

   Humansin individuals with obesity and MASLD

   Circulating Liver-Derived and CD36⁺ Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weight Loss Intervention

   Journal of extracellular vesicles·Mar 1, 2026