Vemurafenib

1 paper2 findings

PubChem ChEBI MeSH

1 lab in 1 country
1 finding against
4 trials, none about aging

Funder: Université de Reims Champagne-Ardenne

Animals1

Outcomes

1

Tumor growth

no changein mice1downin mice1

1 study

Vemurafenib has no effect on tumor growth in mice.
“vemurafenib reduced tumor growth in athymic mice xenografted with melanoma cells embedded in young collagen matrices, but not in those with aged collagen.”
Animalsathymic mice xenografted with melanoma cells embedded in aged collagen matrices
Age-associated changes in type I collagen promote the invasion of BRAFV600E mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieJul 19, 2025
Vemurafenib decreases tumor growth in mice.
“vemurafenib reduced tumor growth in athymic mice xenografted with melanoma cells embedded in young collagen matrices”
Animalsathymic mice xenografted with melanoma cells embedded in young collagen matrices
Age-associated changes in type I collagen promote the invasion of BRAFV600E mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieJul 19, 2025

Trial sponsors

Pfizer
Company1 trialPhase 4210 people
Genentech
Company1 trialPhase 299 people

Latest

1 in 12 months

bioRxivMar 29

Heterogeneous pro-inflammatory response to BRAFV600E-induced thyroid tumor development

Preprint: experiments in miceInflammation

Biomedicine & PharmacotherapyJul 20

Age-associated changes in type I collagen promote the invasion of BRAFV600E mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models

Experiments in miceMechanisms

Breast DiseaseApr 27

Mini review: The FDA-approved prescription drugs that target the MAPK signaling pathway in women with breast cancer

ReviewInterventions