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Type i collagen

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Université de Reims Champagne-Ardenne
  • Animals1

Outcomes

3

Cell invasion

upin human cells1

1 study

  1. Type i collagen increases cell invasion in human cells.

    “aged collagen enhances the invasive properties of 1205Lu cells”

    Cells3D collagen matrix spheroid modelaged collagen matrix1205Lu

    Age-associated changes in type I collagen promote the invasion of BRAFV600E mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieJul 19, 2025

Resistance to vemurafenib

upin human cells1

1 study

  1. Type i collagen increases resistance to vemurafenib in human cells.

    “protects both 1205Lu and SKMEL28 cells from vemurafenib effects.”

    Cells3D culture matrix model of BRAFV600E-mutated melanomaaged collagen matrix1205Lu and SKMEL28

    Age-associated changes in type I collagen promote the invasion of BRAFV600E mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieJul 19, 2025

Cell proliferation

upin human cells1

1 study

  1. Type i collagen increases cell proliferation in human cells.

    “old collagen promotes increased proliferation of 1205Lu cells”

    Cells3D culture matrix model of BRAFV600E-mutated melanomaaged collagen matrix1205Lu

    Age-associated changes in type I collagen promote the invasion of BRAFV600E mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieJul 19, 2025

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