Unemployment

5 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 2 countries

Humans4
In silico1

Associations

3

Primary diagnosis

upin humans1

1 study

Unemployment raises the risk of primary diagnosis in humans (p < 0.001).
“Logistic regression revealed that unemployment, retirement, and not seeking work significantly increased the likelihood of a primary diagnosis ( p < 0.001).”
Humansin Western African = 598
Employment Status, Housing Stability, and Cognitive Health: Socioeconomic Determinants of Alzheimer's Disease and Dementia in Western and Eastern Africa
AAIC 2025 abstract25 Dec 2025

More on Primary diagnosis

Cardiovascular disease mortality

upin humans1RR 1.19

1 study

Unemployment raises the risk of cardiovascular disease mortality in humans (RR 1.19 (95% CI 1.15-1.24)).
“High (compared with low) unemployment rates were associated with increased risk of CVDM (Figure) during the winter [adjusted RR 1.19 (95% CI 1.15-1.24)]”
Humanswintermales
Association of Unemployment Rates and Cardiovascular Disease Mortality in Northeast United States
AHA Scientific Sessions 2025 abstract3 Nov 2025

Premature all-cause mortality

upin humans1+19% paf

1 study

Unemployment is associated with premature all-cause mortality in humans (18.5% PAF).
“unemployment (18.5%), limited English fluency (9.0%), and social isolation (8.3%) showed the highest relative contributions to mortality.”
Humansn = 3,888
PREMATURE DEATH ATTRIBUTABLE TO SOCIAL DETERMINANTS OF HEALTH AMONG ASIAN AMERICANS: A POPULATION-BASED COHORT
GSA 2024 abstract31 Dec 2024

Latest

4 in 12 months

Sante Publique7 Oct

Educational investment as a lever for longevity: An econometric analysis of life expectancy at birth in the Democratic Republic of the Congo

Computational studyPopulations

GSA 2025 Abstract3 Jan

State- and County-Level Social Determinants of Health-Adjusted Life Expectancy

Cohort study in peoplePopulations

AAIC 2025 Abstract25 Dec

Employment Status, Housing Stability, and Cognitive Health: Socioeconomic Determinants of Alzheimer's Disease and Dementia in Western and Eastern Africa

Cross-sectional study of 631 peopleDementia

AHA Scientific Sessions 2025 Abstract3 Nov

Association of Unemployment Rates and Cardiovascular Disease Mortality in Northeast United States

Cohort study of 76,418 peopleCardiovascular disease

GSA 2024 Abstract1 Jan

PREMATURE DEATH ATTRIBUTABLE TO SOCIAL DETERMINANTS OF HEALTH AMONG ASIAN AMERICANS: A POPULATION-BASED COHORT

Cohort study of 3,888 peoplePopulations