AgingResearch.NewsJoin free

UCPH-101

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals1

Outcomes

2

Senescent chondrocytes

downin humans1

1 study

  1. UCPH-101 decreases senescent chondrocytes in humans.

    “Administration of an intraarticular injection of UCPH-101 caused inhibition of EAAT1 selectively, cleared SenChos from cartilage”

    Animalsintraarticular injectioncartilage

    Selective Clearance of Senescent Chondrocytes in Osteoarthritis by Targeting Excitatory Amino Acid Transporter Protein 1 to Induce Ferroptosis

    Antioxidants & redox signaling

More on Senescent chondrocytes

Ferroptosis

upin human cells1

1 study

  1. UCPH-101 increases ferroptosis in human cells.

    “UCPH-101) (a specific inhibitor of EAAT1) and siRNA-EAAT1 were able to substantially increase the sensitivity of SenChos to ferroptosis and to induce cell death”

    Cellssenescent chondrocytes

    Selective Clearance of Senescent Chondrocytes in Osteoarthritis by Targeting Excitatory Amino Acid Transporter Protein 1 to Induce Ferroptosis

    Antioxidants & redox signaling

More on Ferroptosis

Latest

Related