Tripeptidyl peptidase 1

1. Tripeptidyl peptidase 1 improves neurological function in mice.

   “Importantly, IV administration of TPP1 with the peptide significantly reduces brain lysosomal storage, increases lifespan and improves neurological function.”

   Animalsin LINCL micerecombinant TPP1 coadministered with a 36-residue Apolipoprotein E-derived peptide

   Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain

   Molecular therapy : the journal of the American Society of Gene Therapy·26 Dec 2013

1. Tripeptidyl peptidase 1 extends lifespan in mice.

   “Importantly, IV administration of TPP1 with the peptide significantly reduces brain lysosomal storage, increases lifespan and improves neurological function.”

   Animalsin LINCL micerecombinant TPP1 coadministered with a 36-residue Apolipoprotein E-derived peptide

   Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain

   Molecular therapy : the journal of the American Society of Gene Therapy·26 Dec 2013

1. Tripeptidyl peptidase 1 decreases lysosomal storage in mice.

   “Importantly, IV administration of TPP1 with the peptide significantly reduces brain lysosomal storage, increases lifespan and improves neurological function.”

   Animalsin LINCL micerecombinant TPP1 coadministered with a 36-residue Apolipoprotein E-derived peptidebrain

   Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain

   Molecular therapy : the journal of the American Society of Gene Therapy·26 Dec 2013

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