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Tnf-alpha blockade

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 4 more
  • Animals1

Outcomes

1

Platelet hyperreactivity

downin mice1

1 study

  1. Tnf-alpha blockade decreases platelet hyperreactivity in mice.

    “We further showed that platelet hyperreactivity is neutralized by abrogating signaling through TNF-α receptors in vivo in a mouse model of aging.”

    AnimalsTNF-α receptor blockade

    TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

    Blood16 Jul 2019

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