Tdasc-evs

Intervention1 paper4 findings

Animals1

Outcomes

3

Wound closure

upin mice1upin pigs1Very low certainty

1 study

Tdasc-evs improve wound closure in pigs.
Animalsdiabetic large animal model
SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescence via PI3K/AKT/mTOR/4EBP1-mediated cap-dependent translation · Burns & trauma · 22 Jun 2026
Tdasc-evs improve wound closure in mice.
Animalsdiabetic wound model
SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescence via PI3K/AKT/mTOR/4EBP1-mediated cap-dependent translation · Burns & trauma · 22 Jun 2026

PI3K–AKT signalling

upin human cells1Very low certainty

1 study

Tdasc-evs activate PI3K–AKT signalling in human cells.
Cellshigh-glucose-induced HDMECs
SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescence via PI3K/AKT/mTOR/4EBP1-mediated cap-dependent translation · Burns & trauma · 22 Jun 2026

PI3K–AKT signalling →

Senescence

downin human cells1Very low certainty

1 study

Tdasc-evs decrease senescence in human cells.
Cellshigh-glucose-induced
SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescence via PI3K/AKT/mTOR/4EBP1-mediated cap-dependent translation · Burns & trauma · 22 Jun 2026

Latest

1

Burns & TraumaAnimals14 Sep

SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescence via PI3K/AKT/mTOR/4EBP1-mediated cap-dependent translation