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TCO-ARV-771

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of General Medical Sciences and 2 more
  • Cells1

Outcomes

1

BRD4

downin human cells1

1 study

  1. TCO-ARV-771 decreases BRD4 in human cells.

    “PROTAC prodrug TCO-ARV-771 can be selectively activated by Gal-Tz and delivered into senescent HeLa and A549 cells to induce the degradation of bromodomain-containing protein 4.”

    Cellsactivated by Gal-Tz in senescent HeLa and A549 cells

    Senolysis Enabled by Senescent Cell-Sensitive Bioorthogonal Tetrazine Ligation

    Angewandte Chemie (International ed. in English)18 Jan 2024

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