Systemic ablation of P16-EXPRESSING cells

1. Systemic ablation of P16-EXPRESSING cells improve coronary flow reserve in mice (Restored to control levels).

   “systemic ablation of p16-expressing cells (i.e., p16high cells), reversed IH-induced hypertension and restored coronary flow reserve to control levels.”

   Animalsintermittent hypoxia-exposed p16-CreERT2-DTR-tdTomato miceheart

   Intermittent Hypoxia Mimicking Sleep Apnea Induces Systemic and Tissue Specific Epigenetic Changes and p16-Mediated Cellular Senescence Underlying Vascular Dysfunction

   Research square·Apr 15, 2026Preprint

1. Systemic ablation of P16-EXPRESSING cells decrease hypertension in mice.

   “systemic ablation of p16-expressing cells (i.e., p16high cells), reversed IH-induced hypertension and restored coronary flow reserve to control levels.”

   Animalsintermittent hypoxia-exposed p16-CreERT2-DTR-tdTomato mice

   Intermittent Hypoxia Mimicking Sleep Apnea Induces Systemic and Tissue Specific Epigenetic Changes and p16-Mediated Cellular Senescence Underlying Vascular Dysfunction

   Research square·Apr 15, 2026Preprint

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