Supramolecular senolytics via intracellular oligomerization of peptides

1. Supramolecular senolytics via intracellular oligomerization of peptides improve visual function in mice.

   “and this effect was accompanied by improved visual function.”

   Animalsin an age-related macular degeneration mouse model and in aged mice

   Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

   Journal of the American Chemical Society·Sep 4, 2023

1. Supramolecular senolytics via intracellular oligomerization of peptides protect against retinal degeneration in mice.

   “Significant reductions in key senescence markers and amelioration of retinal degeneration were observed after elimination of the senescent retinal pigment epithelium by this peptide senolytic”

   Animalsin an age-related macular degeneration mouse model and in aged miceretina

   Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

   Journal of the American Chemical Society·Sep 4, 2023

More on Retinal degeneration

1. Supramolecular senolytics via intracellular oligomerization of peptides decrease cellular senescence in mice.

   “Significant reductions in key senescence markers and amelioration of retinal degeneration were observed after elimination of the senescent retinal pigment epithelium by this peptide senolytic”

   Animalsin an age-related macular degeneration mouse model and in aged miceretina

   Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

   Journal of the American Chemical Society·Sep 4, 2023

More on Cellular senescence