Sodium benzoate

3 papers study it1 more mentions it8 findings

Outcomes

Lifespan

downin worms2downin flies1

3 studies

Sodium benzoate shortens lifespan in worms.
“Lifespan analysis also demonstrated that SB significantly reduced lifespan in wild-type worms, even at low concentrations.”
Model organismswild-type worms, including low concentrations
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model
NutrientsOct 31, 2024
Sodium benzoate shortens lifespan in worms.
“Lifespan analysis also demonstrated that SB significantly accelerated aging in wild-type worms in a dose-dependent manner.”
Model organisms
Sodium Benzoate Promotes Fat Accumulation and Aging via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model
bioRxiv (Cold Spring Harbor Laboratory)Sep 21, 2024Preprint
Sodium benzoate shortens lifespan in flies.
“SB significantly retarded the development of D. melanogaster larvae, shortened the life span, and changed the commensal microbial community.”
Model organisms
Sodium Benzoate Delays the Development of Drosophila melanogaster Larvae and Alters Commensal Microbiota in Adult Flies
Frontiers in microbiologyJun 22, 2022

Fat accumulation

upin worms2

2 studies

Sodium benzoate increases fat accumulation in worms.
“SB induced more fat accumulation compared to vehicle control, even at low concentrations, including the dosage of 0.0004%.”
Model organismswild-type worms; compared with vehicle controlincluding 0.0004%72 h
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model
NutrientsOct 31, 2024
Sodium benzoate increases fat accumulation in worms.
“SB induced more fat accumulation compared to vehicle control, even at low concentrations, including the dosage of 0.0004%.”
Model organisms
Sodium Benzoate Promotes Fat Accumulation and Aging via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model
bioRxiv (Cold Spring Harbor Laboratory)Sep 21, 2024Preprint

SKN-1 nuclear localization

downin worms1

1 study

Sodium benzoate inhibits SKN-1 nuclear localization in worms.
“Moreover, SB inhibited the nuclear localization of SKN-1 under oxidative stress conditions.”
Model organismsunder oxidative stress conditions
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model
NutrientsOct 31, 2024