Socialization

4 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Human trial1
Humans3

Outcomes

Memory

no changein humans1

1 study

Socialization has no effect on memory in humans (β = .222, p = .103).
“not memory composite (β = .222 p = .103) nor executive function composite (β = .215 p = .114)”
Humansn = 55
EMA‐Derived Daily Socialization in Younger Older Adults with and without Cognitive Impairment
AAIC 2025 abstract26 Dec 2025

Depression

mediatesin humans1

1 study

Socialization mediates depression in humans (13.29% of the total effect).
“Socialization was a partial mediating variable in the relationship between incapacitation and depression in the aged, and its mediating effect accounted for 13.29% of the total effect.”
HumansStatistical mediation of the relationship between disability and depression
The impact of disability status on depression in the aged with the moderating effect of community support
BMC psychology29 Sep 2025

Associations

Language ability

upin humans1

1 study

Socialization is associated with language ability in humans (β = .299, p = .027).
“higher language composite (β = .299 p = .027)”
Humansn = 55
EMA‐Derived Daily Socialization in Younger Older Adults with and without Cognitive Impairment
AAIC 2025 abstract26 Dec 2025

Cognitive function

upin humans1

1 study

Socialization is associated with cognitive function in humans (β = .289, p = .027).
“higher daily socialization was significantly associated with higher cognitive composite (β = .289 p = .027)”
Humansn = 55
EMA‐Derived Daily Socialization in Younger Older Adults with and without Cognitive Impairment
AAIC 2025 abstract26 Dec 2025