Small intestinal epithelium-derived exosomes

1. Small intestinal epithelium-derived exosomes increase lipid-droplet in mice.

   “Inhibition of Usp34 downregulated the Wnt/β-catenin pathway, promoting lipid droplet formation and differentiation of PDGFRα+ progenitor cells.”

   Animalsyoung SI-Exos treatment in aged mice

   From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRα⁺ Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging

   Aging cell·1 Jul 2026

1. Small intestinal epithelium-derived exosomes decrease inflammation in mice.

   “Administration of young SI-Exos to aged mice enhanced lipid droplet formation, reversed SAT atrophy, and reduced inflammation in visceral adipose tissue (VAT).”

   Animalsagingvisceral adipose tissue

   From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRα⁺ Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging

   Aging cell·1 Jul 2026

More on Inflammation

1. Small intestinal epithelium-derived exosomes decrease subcutaneous adipose tissue atrophy in mice.

   “Administration of young SI-Exos to aged mice enhanced lipid droplet formation, reversed SAT atrophy, and reduced inflammation in visceral adipose tissue (VAT).”

   Animalsaging

   From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRα⁺ Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging

   Aging cell·1 Jul 2026

More on Subcutaneous adipose tissue atrophy