SIRT1 agonists

1. SIRT1 agonists increase C1QB in mice.

   “Sirt1 agonists inhibited the decrease in C1qb in macrophages during aging”

   Animalsin macrophages during aging

   Tissue-resident C1q + macrophages exert anti-aging potential through the Sirt1 pathway

   Inflammation research : official journal of the European Histamine Research Society ... [et al.]·May 9, 2024

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1. SIRT1 agonists improve immune response in mice.

   “SIRT1 agonists partially restored the impaired innate immune responses in senescent cells and aged mice”

   Animals

   IRF3 and IRF7 require SIRT1 for liquid-liquid phase separation and transactivation of IFN-1

   Nature immunology·Jul 26, 2022

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1. SIRT1 agonists inhibit viral replication in mice.

   “SIRT1 agonists rescued SIRT1 activity in aged mice, restored IFN signaling and thus antagonized viral replication.”

   Animalsin aged mice

   Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/IRF7 in innate antiviral immunity

   Nature immunology·Jul 25, 2022

1. SIRT1 agonists activate type I interferon signalling in mice.

   “SIRT1 agonists rescued SIRT1 activity in aged mice, restored IFN signaling and thus antagonized viral replication.”

   Animalsin aged mice

   Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/IRF7 in innate antiviral immunity

   Nature immunology·Jul 25, 2022

More on Type I interferon signalling