Shingles vaccine
2 papers7 findings
- 2 independent labs in 1 country
- 1 finding against
- Funders: National Institute on Aging and 1 more
- Humans2
Outcomes
6Adaptive immunity score
upin humans1
1 study
Adaptive immunity score
upin humans1
Shingles vaccine increases adaptive immunity score in humans (b = 0.09, p = .0133).
“vaccination was linked to higher adaptive immunity scores (b = 0.09, p = .0133)”
Humansn = 3,884
The journals of gerontology. Series A, Biological sciences and medical sciences20 Jan 2026
Composite biological aging score
downin humans1
1 study
Composite biological aging score
downin humans1
Shingles vaccine decreases composite biological aging score in humans (b = -0.18, p = .0002).
“and a lower composite biological aging score (b = -0.18, p = .0002)”
Humansn = 3,884
The journals of gerontology. Series A, Biological sciences and medical sciences20 Jan 2026
Transcriptomic aging
downin humans1
1 study
Transcriptomic aging
downin humans1
Shingles vaccine decreases transcriptomic aging in humans (b = -0.19, p < .0001).
“transcriptomic aging (b = -0.19, p < .0001)”
Humansn = 3,884
The journals of gerontology. Series A, Biological sciences and medical sciences20 Jan 2026
Epigenetic aging
downin humans1
1 study
Epigenetic aging
downin humans1
Shingles vaccine decreases epigenetic aging in humans (b = -0.17, p = .0001).
“slower epigenetic (b = -0.17, p = .0001) and transcriptomic aging”
Humansn = 3,884
The journals of gerontology. Series A, Biological sciences and medical sciences20 Jan 2026
Inflammation score
downin humans1
1 study
Inflammation score
downin humans1
Shingles vaccine decreases inflammation score in humans (b = -0.14, p = .0027).
“Shingles vaccination was significantly associated with lower inflammation scores (b = -0.14, p = .0027)”
Humansn = 3,884
The journals of gerontology. Series A, Biological sciences and medical sciences20 Jan 2026
Alzheimer's disease
no changein humans1OR 0.9
1 study
Alzheimer's disease
no changein humans1OR 0.9
Shingles vaccine has no effect on Alzheimer's disease in humans (OR=0.90, p-value=0.81).
“In non‐carriers, the association between the shingles vaccine and AD became non‐significant (OR=0.90, p ‐value=0.81).”
Humansrs6859 (A) non-carriers
AAIC 2025 abstract23 Dec 2025
Associations
1Alzheimer's disease
downin humans1OR 0.55
1 study
Alzheimer's disease
downin humans1OR 0.55
Shingles vaccine lowers the risk of Alzheimer's disease in humans (OR=0.55, p-value=0.021).
“Shingles vaccine received at ages 65–75 was associated with significantly lower odds of AD onset after age 75 (OR=0.55, p ‐value=0.021) in an unstratified HRS sample.”
Humansunstratified sample
AAIC 2025 abstract23 Dec 2025