SB225002

1. SB225002 decreases cellular senescence in human cells.

   “Here, we demonstrate the possibility to counteract both the autocrine senescence in LAM/TSC cells and senescence induced on PLFs by inhibiting CXCR2”

   Cellsin LAM/TSC cells

   Interleukin-8 and extracellular vesicles spread senescence in Lymphangioleiomyomatosis microenvironment

   Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·Jun 11, 2026

2. SB225002 decreases cellular senescence in mice.

   “Administration of SB225002, a selective CXCR2 antagonist, significantly inhibited the activation of β-catenin signaling, restored mitochondrial function, protected against tubular cell senescence and renal fibrosis in unilateral ureteral obstruction (UUO) mice.”

   Animalsunilateral ureteral obstructionkidney

   CXC Chemokine Receptor 2 Accelerates Tubular Cell Senescence and Renal Fibrosis via β-Catenin-Induced Mitochondrial Dysfunction

   Frontiers in cell and developmental biology·May 3, 2022

More on Cellular senescence

1. SB225002 decreases IL-8 in human cells.

   “revealed significant upregulation of pathogenic factors such as IL-8 and IL-17, which were attenuated by SB225002 (anti-CXCR2) and secukinumab (anti-IL-17A).”

   Cellsin CEnCs after chronic UV-A and 4-OHE2 exposurecorneal endothelium

   p16-mediated G0/G1 cell cycle arrest leads to SASP and fibrosis in Fuchs endothelial corneal dystrophy

   Cell death & disease·Feb 2, 2026

More on IL-8

1. SB225002 decreases renal fibrosis in mice.

   “Administration of SB225002, a selective CXCR2 antagonist, significantly inhibited the activation of β-catenin signaling, restored mitochondrial function, protected against tubular cell senescence and renal fibrosis in unilateral ureteral obstruction (UUO) mice.”

   Animalsunilateral ureteral obstructionkidney

   CXC Chemokine Receptor 2 Accelerates Tubular Cell Senescence and Renal Fibrosis via β-Catenin-Induced Mitochondrial Dysfunction

   Frontiers in cell and developmental biology·May 3, 2022