Roflumilast
Intervention1 paper2 findingsPubChem 449193ChEBI 47657
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
- Model organisms1
Outcomes
2Cellular senescence
downin mouse cells1
1 study
Cellular senescence
downin mouse cells1
Roflumilast decreases cellular senescence in mouse cells.
Cellspassage-induced cellular senescencemouse embryonic fibroblast
Two PDE4 inhibitors extend lifespan in worms · Free radical biology & medicine · 8 Oct 2026
Lifespan
upin worms1
1 study
Lifespan
upin worms1
Roflumilast extends lifespan in worms.
Model organisms
Two PDE4 inhibitors extend lifespan in worms · Free radical biology & medicine · 8 Oct 2026
Latest
1Two PDE4 inhibitors extend lifespan in worms
In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial…In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated oxidative stress.