RN-1

1. RN-1 decreases reactive oxygen species in mice.

   “reduced ROS accumulation in parallel with reducing mitochondria-retaining RBCs in the SCD mouse model.”

   Animalsin the SCD mouse model

   Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

   Experimental hematology·24 Feb 2017

More on Reactive oxygen species

1. RN-1 improves red blood cell lifespan in mice.

   “the LSD1 inhibitor, RN-1, and the mitophagy-inducing agent mammalian target of rapamycin (mTOR) inhibitor, sirolimus, increased RBC lifespan”

   Animalsin the SCD mouse model

   Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

   Experimental hematology·24 Feb 2017