Mitochondria-retaining red blood cells

1. Rapamycin decreases mitochondria-retaining red blood cells in mice.

   “reduced ROS accumulation in parallel with reducing mitochondria-retaining RBCs in the SCD mouse model.”

   Animalsin the SCD mouse model

   Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

   Experimental hematology·24 Feb 2017

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1. Sickle cell disease increases mitochondria-retaining red blood cells in humans.

   “we observed an increased percentage of RBCs retaining mitochondria in SCD patient blood samples compared with healthy individuals.”

   Humansin SCD patient blood samples compared with healthy individuals

   Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

   Experimental hematology·24 Feb 2017

More on Sickle cell disease